张强，博士，副教授，硕士生导师
研究方向：
肠道微生物稳态与人体健康；新型抗病毒分子的研制与诊断制剂的开发。
教育经历：
2005.9-2009.6 山东农业大学，动物医学，学士
2009.9-2015.6 华中农业大学，预防兽医学，博士
工作经历：
2015.7-2020.9 华中农业大学，生命科学技术学院，博士后
2020.9至今 华中农业大学，副教授
发表论文：
1) Li B#, Zhao Y#, Wu X, Wu H, Tang W, Yu X, Mou J, Tan W, Jin M*, Li W*, Zhang Q*, and Liu M*. Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV‑2 Variants. ACS Nano. 2023;17(7):7017-7034. (共同通讯，IF: 18.027)
2) Zhang Q, Hu J, Feng J, Hu X, Wang T, Gong W, Huang K, Guo Y,Zou Z, Lin X, Zhou R, Yuan Y, Zhang A, Wei H, Cao G, Liu C*, Chen L*, Jin M*, Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020, 21(1):99. (IF: 13.583)
3) Li R#, Zhao Y#, Fan H#, Chen M, Hu W, Zhang Q*, Jin M*, Liu GL*, Huang L*. Versatile nanorobot hand biosensor for specific capture and ultrasensitive quantification of viral nanoparticles. Mater Today Bio. 2022;16:100444. (共同通讯，IF: 10.761)
4) Zhao Y#, Li R#, Lv C, Zhang Y, Zhou H, Xia X, Yu S, Wang Y, Huang L*, Zhang Q*, Liu GL*, Jin M*. One-Step Rapid and Sensitive ASFV p30 Antibody Detection via Nanoplasmonic Biosensors. Microbiol Spectr. 2022: e0234322. (共同通讯，IF: 9.043)
5) Zhang Q#, Zhang H#, Gao J#, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z*, Shi Z*, Jin M*. A serological survey of SARS-CoV-2 in cat in Wuhan. Emerg Microbes Infect. 2020, 9(1):2013-2019. (IF:7.163)
6) Zhong ZJ, Hu XT, Cheng LP*, Zhang XY, Zhang Q*, Zhang J. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors. Eur J Med Chem. 2021, 225:113762. (共同通讯，IF: 6.514)
7) Hu X, Zhao Y, Yang Y, Gong W, Sun X, Yang L, Zhang Q*, Jin M*. Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection. Front Microbiol. 2021, 11:586476. (共同通讯，IF:5.64)
8) Zhao Y#, Yang Y#, Gao J, Huang K, Hu C, Hui X, He X, Li C, Gong W, Lv C, Zhang Y, Chen H, Zou Z, Zhang Q*, Jin M*. A serological survey of severe acute respiratory syndrome coronavirus 2 in wuhan. Transbound Emerg Dis. 2021. doi: 10.1111/tbed.14024. (共同通讯，IF:5.005)
9) Hui X, Xu Z, Cao L, Liu L, Lin X, Yang Y, Sun X, Zhang Q*, Jin M*. HP0487 contributes to the virulence of Streptococcus suis serotype 2 by mediating bacterial adhesion and anti-phagocytosis to neutrophils. Vet Microbiol. 2021, 260:109164. (共同通讯，IF:3.293)
10) Wu C, Lv C, Zhao Y, Zhu W, Liu L, Wang T, Kang C, Yang Y, Sun X, Zhang Q*, Jin M*. Characterization of Erysipelothrix rhusiopathiae Isolates from Diseased Pigs in 15 Chinese Provinces from 2012 to 2018. Microorganisms. 2021; 9(12):2615. (共同通讯，IF: 4.128)
11) Yang H#, Huang J#, Hu X, Hu M, Zhang Q*, Jin M*. Comparative Genome Analysis of Streptococcus suis Serotype 9 Isolates from China, The Netherland, and the U.K. Life. 2021; 11(12):1324. (共同通讯，IF: 3.817)
12) Lv C#, Zhao Y#, Jiang L, Zhao L, Wu C, Hui X, Hu X, Shao Z, Xia X, Sun X, Zhang Q*, Jin M*. Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV. Life. 2021; 11(11):1214. (共同通讯，IF: 3.817)
13) Yang Y, Lv C, Fan J, Zhao Y, Jiang L, Sun X, Zhang Q*, Jin M*. Development of a chemiluminescence immunoassay to accurately detect African swine fever virus antibodies in serum. J Virol Methods. 2021, 298:114269. (共同通讯，IF:2.014)
14) Zhang Q#, Huang J#, Yu J, Xu Z, Liu L, Song Y, Sun X, Zhang A* and Jin M*, HP1330 Contributes to Streptococcus suis Virulence by Inducing TLR2- and ERK1/2-Dependent Pro-inflammatory Responses and Influencing In Vivo S. suis Loads, Front Immunol. 2017, 8:869. (IF:7.561)
15) Huang K#, Zhang Q#, Song Y, Zhang Z, Zhang A, Xiao J, Jin M*, Characterization of Spectinomycin Resistancein Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism, Antimicrob Agents Chemother. 2016, 7.25, (60): 6390~6392. (共一，IF:5.191)
16) Zhang Q#, Yang Y#, Yan S, Liu J, Xu Z, Yu J, Song Y, Zhang A, Jin M*, A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway, Front Microbiol. 2015, 6: 178. (IF:5.64)
17) Zhang Q, Liu J, Yan S, Yang Y, Zhang A, Jin M*. Fluoroquinolone-resistant Haemophilus parasuis isolates exhibit more putative virulence factors than their susceptible counterparts. J Clin Microbiol. 2013, 51(9):3130-1. (IF:5.948)
18) Zhang Q, Zhou M, Song D, Zhao J, Zhang A, Jin M*. Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China. Int J Antimicrob Agents. 2013 Jul;42(1):87-9. (IF:5.283)
19) Zhou M#, Zhang Q#, Zhao J, Jin M*. Haemophilus parasuis encodes two functional cytolethal distending toxins: CdtC contains an atypical cholesterol recognition/interaction region. PLoS One. 2012,7(3):e32580. (共一，IF:3.24)
20) Huang K#, Zhang Y#, Hui X, Zhao Y, Gong W, Wang T, Zhang S, Yang Y, Deng F, Zhang Q, Chen X, Yang Y, Sun X, Chen H, Tao YJ, Zou Z*, Jin M*. Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice. EBioMedicine. 2021, 67:103381.
21) Zhang Y#, Huang K#, Wang T, Deng F, Gong W, Hui X, Zhao Y, He X, Li C, Zhang Q, Chen X, Lv C, Lin X, Yang Y, Sun X, Shi Z, Chen H, Zou Z*, Jin M*. SARS-CoV-2 rapidly adapts in aged BALB/c mice and induces typical pneumonia. J Virol. 2021, 95(11):e02477-20.
22) Liu L, Zhang Q, Xu Z, Chen B, Zhang A, Sun X, Jin M*. Screening of Virulence-Related Transcriptional Regulators in Streptococcus suis. Genes (Basel). 2020, 11(9): E972.
23) Li C, He X, Yang Y, Gong W, Huang K, Zhang Y, Yang Y, Sun X, Ren W, Zhang Q, Wu X*, Zou Z*, Jin M*. Rapid and visual detection of African swine fever virus antibody by using fluorescent immunochromatography test strip. Talanta. 2020, 219:121284.
24) Liu L, Zhang Q, Xu Z, Huang J, Zhu W, Zhang A, Sun X, Jin M*. HP1717 Contributes to Streptococcus suis Virulence by Inducing an Excessive Inflammatory Response and Influencing the Biosynthesis of the Capsule. Microorganisms, 2019, 7:11.
25) Zhu W, Cai C, Li J, Zhang Q, Huang J, Jin M*. Characterization of protective antigen CbpB as an adhesin and a plasminogen-binding protein of Erysipelothrix rhusiopathiae. Res Vet Sci. 2019, 124:352-356.
26) Xu Z, Chen B, Zhang Q, Liu L, Zhang A, Yang Y, Huang K, Yan S, Yu J, Sun X, Jin M*, Streptococcus suis 2 transcriptional regulator TstS stimulates cytokine production and bacteremia to promote streptococcal toxic shock-like syndrome, Front Microbiol, 2018, 9:1309.
27) Zhu W, Wu C, Kang C, Cai C, Wang Y, Li J, Zhang Q, Sun X, Jin M*. Evaluation of the protective efficacy of four newly identified surface proteins of Erysipelothrix rhusiopathiae. Vaccine. 2018, 36(52):8079-8083.
28) Zhu W, Zhang Q, Li J, Wei Y, Cai C, Liu L, Xu Z, Jin M*, Glyceraldehyde-3-phosphate dehydrogenase acts as an adhesin in Erysipelothrix rhusiopathiae adhesion to porcine endothelial cells and as a receptor in recruitment of host fibronectin and plasminogen, Vet Res, 2017, 48:16.
29) Wang Y, Li J, Zhang A, Zhu W, Zhang Q, Xu Z, Yan S, Sun X, Chen H, Jin M*, iTRAQ-based quantitative proteomic analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae, Journal of Proteomics, 2017, 160: 28–37.
30) Kang C, Zhang Q, Zhu W, Cai C, Sun X, Jin M*, Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae, PLoS ONE, 2017, 12(10): e0185548.
31) Fu L, Zhao J, Lin L, Zhang Q, Xu Z, Han L, Xie C, Zhou R, Jin M, Zhang A*, Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype2, Microbes and Infection, 2016, 1.14, (18): 285~289.
32) Huang K, Song Y, Zhang Q, Zhang A, Jin M. Characterisation of a novel integrative and conjugative element ICESsD9 carrying erm(B) and tet(O) resistance determinants in Streptococcus suis, and the distribution of ICESsD9-like elements in clinical isolates. J Glob Antimicrob Resist. 2016, 13-18.
33) Huang K, Yuan Z, Liu J, Zhang Q, Xu Z, Yan S, Zhang A, Jin M*. Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2. Microbiol Res. 2015, 170:168-176.
34) Wang N, Zou W, Yang Y, Guo X, Hua Y, Zhang Q, Zhao Z, Jin M*. Complete Genome Sequence of an H10N5 Avian Influenza Virus Isolated from Pigs in Central China, Journal of Virology, 2012, 86(24), pp 13865-13866.
出版著作：
1) （作者以姓氏汉语拼音为序）贝为成，陈焕春，何启盖，胡进，金梅林*，康超，钱伟，石德时，孙小美，谭臣，汤细彪，王婷，王湘如，吴斌，徐高原，许仲旻，张强，张安定，《猪链球菌致病分子基础与防控技术》，北京，科学出版社，380千字，2018.
2) （以姓氏笔画为序）王磊，占玲俊*，史利军，李蓓，李冬青，张强，金梅林*，柯跃华，郭玺，唐军，崔步云，崔尚金，《比较传染病学—细菌性疾病》，北京，科学出版社，372千字，2023.
授权专利：
1) 金梅林、张强、胡晓通、杨丽、王婷、孙小美、康超、钟鸣，缬氨酸在制备治疗或预防禽流感病毒感染的药物中的应用，国际发明专利（美国），专利号：US20210220311A1
2) 金梅林，张强，胡晓通，杨丽，王婷，孙小美，康超，钟鸣，缬氨酸在制备治疗或预防禽流感病毒感染的药物中的应用，2020-1-16，中国，ZL202010048679.7
3) 金梅林，张强，胡晓通，杨丽，动物双歧杆菌及其制备的复合菌制剂在制备治疗或预防禽流感病毒感染的药物中的应用，2020-1-13，中国，ZL202010031196.6
4) 金梅林，杨永，张强，赵亚，孙小美，吕长杰，杨丽，一种非洲猪瘟病毒截短蛋白及其在制备ELISA检测试剂盒中的应用，2020-7-20，中国，ZL202010700335.X
5) 金梅林，杨永，张强，赵亚，孙小美，吕长杰，杨丽，一种非洲猪瘟病毒截短蛋白p54制备的单克隆抗体及其应用，2020-7-20，中国，ZL202010698954.X
6) 金梅林，赵建平，周明光，宋岱松，张强，张安定，石建，康超，徐高原，陈焕春，表达副猪嗜血杆菌表面抗原的猪霍乱沙门氏菌减毒疫苗，2015.10.28，中国，ZL201310039113.8
7) 金梅林，赵建平，周明光，宋岱松，张强，张安定，石建，康超，徐高原，陈焕春，一种副猪嗜血杆菌减毒沙门氏菌苗，2015.10.28，中国，ZL201310039080.7
8) 金梅林，赵建平，周明光，宋岱松，张强，张安定，石建，康超，徐高原，陈焕春，一种副猪嗜血杆菌-猪霍乱沙门氏菌二联基因工程苗，2015.10.28，中国，ZL201310040712.1
获得奖项：
金梅林，康超，谭臣，汤细彪，张安定，王湘如，张强，徐高原，吴斌，张锦军，周明光，陈关平，魏燕鸣，钟鸣，贝为成，钱平，陈幕琳，孙小美，陈波，尹争艳。猪链球菌病高效安全防控技术集成与推广应用，湖北省成果推广奖一等奖，2018.12。
基金项目：
1) 国家自然科学基金面上项目，32172891，流感病毒感染诱导肠道代谢分子GlcNAc合成及其抗流感作用机制的研究，2022/01-2025/12，58万元，在研，主持
2) 国家自然科学基金青年科学基金项目，31702253，猪链球菌表面蛋白ZnMc诱导过度炎症反应的分子机制研究，2018/1-2020/12，26万元，已结题，主持
3) 国家重点研发计划，2022YFC0867900，动物用****疫苗的研究开发，2022/01-2022/12,1000万元（本人可支配金额50万元），在研，骨干
4) 国家重点研发计划，2016YFD0500801，家禽重大疫病诊断新技术研究，2016/7-2020/12，693万元（本人可支配金额70万元），已结题，骨干
5) 湖北省重点研发计划，2021ACB004，变异新冠病毒预警及风险评估体系建设，2021/01-2021/12，400万元（本人可支配金额20万元），在研，骨干
6) 国家重点研发计划，2020YFC0845800，新型冠状病毒感染不同进程与宿主的相互作用研究，400万元（本人可支配金额20万元），2020/3-2021/6, 已结题，骨干
7) 中国博士后科学基金面上项目一等资助， 2015M580654，猪链球菌2型抑炎蛋白HP1914作用机制的研究，2015/11-2017/11,8万元，已结题，主持
8) 江夏实验室生物安全科技重大项目，JXBS003，动物用新冠病毒通用疫苗的研究及开发， 2022/01-2024/12,300万元（本人可支配金额30万元），在研，骨干
9) 湖北省重大专项，2020ABA016，主要动植物品种选育及生物制品研发， 2020/11-2023/12,630万元（本人可支配金额20万元），在研，骨干
10) 湖北省新型肺炎应急科技攻关项目，2020FCA001，新型冠状病毒快速检测技术产品研发，86万元（本人可支配金额10万元），2020/1-2020/12,已结题，骨干
11) 湖北省技术创新专项重大项目，2019ABA089,非洲猪瘟防控关键技术研究与示范，500万元（本人可支配金额10万元），2019/1-2021/12，已结题，骨干
12) 新进教师科研启动专项，2662021SYQD002，流感病毒感染诱导肠道代谢分子GlcNAc的合成及其抗流感作用机制的研究，2021/01-2020/12，20万，在研，主持
联系方式（邮箱）：
zhangq_0401@mail.hzau.edu.cn
